[The search for new antiparasitic agents. 11. The acute toxicity and anticestodal activity of the new anthelmintic Tizanox compared with Azinox]

Autor:	Fs, Mikhaĭlitsyn, Felix Kovalenko, Nl, Sergovskaia, Mn, Lebedeva, Vi, Dzhabarova, Nd, Lychko, As, Naĭdenova
Rok vydání:	1992
Předmět:	Male Hymenolepiasis Mesocricetus Thiadiazines Drug Evaluation Preclinical Anticestodal Agents Isoquinolines Praziquantel Lethal Dose 50 Mice Echinococcosis Cricetinae Animals Female
Zdroj:	Europe PubMed Central
ISSN:	0025-8326
Popis:	A synthesis is described and the results of toxicological trial of the potential anthelmintic agent G-1587 are presented. The agent is 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-2H-[1, 2,5] thiadiazino [3,2-a] isoquinoline-4,4-dioxide. The agent was shown to have a low toxicity, the maximal sublethal dose for mice being 4.0 g/kg when given per os.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2164bfee27cbc2176d5315c0dd5c7f51 https://pubmed.ncbi.nlm.nih.gov/1435534 Zobrazit plný text záznamu