Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration
| Autor: | Carnicella, Sebastien, He, Dao-Yao, Yowell, Quinn V., Glick, Stanley D., Ron, Dorit |
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| Přispěvatelé: | ANTE-INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement, Department of neurology, University of California [San Francisco] (UCSF), University of California-University of California-University of California [San Francisco] (UCSF), University of California-University of California-Department of Neurology, University of California-University of California, Center of Neuropharmacology and Neuroscience, Albany Medical College, Department of Neurology, State of California for Medical Research on Alcohol and Substance Abuse through the University of California, San Francisco (D.R.), Department of the Army, Grant # W81XWH-07-1-0079 (D.R.), Savasta, Marc, University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC)-University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC)-Department of Neurology, University of California (UC)-University of California (UC) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
MESH: Cell Line Tumor MESH: Gene Expression Alcohol Drinking MESH: Rats MESH: Motivation Gene Expression MESH: Conditioning Operant Self Administration MESH: Alcohol Deterrents Article MESH: Rats Long-Evans MESH: Alcoholism Cell Line Tumor 18-Methoxycoronaridine Animals Humans Rats Long-Evans MESH: Animals RNA Messenger [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Ibogaine MESH: RNA Messenger Motivation MESH: Humans Ventral Tegmental Area ibogaine GDNF MESH: Male Rats Alcoholism nervous system noribogaine MESH: Ventral Tegmental Area Conditioning Operant [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Ethanol self-administration MESH: Alcohol Drinking MESH: Self Administration Alcohol Deterrents |
| Zdroj: | Addiction Biology Addiction Biology, Wiley, 2010, 15 (4), pp.424-33. ⟨10.1111/j.1369-1600.2010.00251.x⟩ Addiction Biology, 2010, 15 (4), pp.424-33. ⟨10.1111/j.1369-1600.2010.00251.x⟩ |
| ISSN: | 1355-6215 1369-1600 |
| DOI: | 10.1111/j.1369-1600.2010.00251.x⟩ |
| Popis: | Carnicella S present adress: Grenoble Institut des Neurosciences, Inserm U836; International audience; Ibogaine is a naturally occurring alkaloid that has been reported to decrease various adverse phenotypes associated with exposure to drugs of abuse and alcohol in human and rodent models. Unfortunately, ibogaine cannot be used as a medication to treat addiction because of severe side effects. Previously, we reported that the desirable actions of ibogaine to reduce self-administration of, and relapse to, alcohol consumption are mediated via the upregulation of the expression of the glial cell line-derived neurotrophic factor (GDNF) in the midbrain ventral tegmental area (VTA), and the consequent activation of the GDNF pathway. The ibogaine metabolite, noribogaine, and a synthetic derivative of ibogaine, 18-Methoxycoronaridine (18-MC), possess a similar anti-addictive profile as ibogaine in rodent models, but without some of its adverse side effects. Here, we determined whether noribogaine and/or 18-MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA. We used SH-SY5Y cells as a cell culture model and found that noribogaine, like ibogaine, but not 18-MC, induces a robust increase in GDNF mRNA levels. Next, we tested the effect of intra-VTA infusion of noribogaine and 18-MC on rat operant alcohol self-administration and found that noribogaine, but not 18-MC, in the VTA decreases responding for alcohol. Together, our results suggest that noribogaine and 18-MC have different mechanisms and sites of action. |
| Databáze: | OpenAIRE |
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