Notch receptors in human choroid plexus tumors
| Autor: | Rudi Beschorner, Waidelich J, Trautmann K, Psaras T, Schittenhelm J |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Choroid Plexus Neoplasms Adolescent Receptor ErbB-2 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU] Young Adult Her2 Humans Child neoplasms Receptor Notch3 Aged Aged 80 and over Receptors Notch Gene Expression Profiling Carcinoma Infant Newborn Brain Infant Middle Aged Immunohistochemistry Gene Expression Regulation 5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología [CDU] Child Preschool Notch receptors Choroid Plexus Female Autopsy |
| Zdroj: | DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname Europe PubMed Central |
| ISSN: | 1699-5848 |
| Popis: | Notch signaling plays a role in development and formation of the normal choroid plexus (nCP), and in formation of various tumors in humans. Activation of Notch3 has been reported to promote tumor growth in invasive gliomas and to initiate formation of choroid plexus tumors (CPT) in mice. We investigated the expression of all currently known Notch receptors (Notch 1-4) in 55 samples of nCP and 88 CPT, including 61 choroid plexus papillomas (CPP), 22 atypical CPP and 5 choroid plexus carcinomas by immunohistochemistry. Notch expression was semiquantitatively evaluated separately for membranous/cytoplasmic and for nuclear staining. In addition, we examined Her2 expression (EGFR2, Her2/neu, ErbB2, CD340) because of its functional link to Notch signaling. All samples were negative for Notch3. Membranous/cytoplasmic expression of Notch1 (p |
| Databáze: | OpenAIRE |
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