Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics

Autor:	Balint, Bettina, Wiethoff, Sarah, Martino, Davide, del Gamba, Claudia, Latorre, Anna, Ganos, Christos, Houlden, Henry, Bhatia, Kailash P.
Rok vydání:	2018
Předmět:	tics Case Series PRRT2 nervous system diseases paroxysmal kinesigenic dyskinesia (PKD)
Zdroj:	Movement Disorders Clinical Practice
ISSN:	2330-1619
Popis:	Background Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement. Methods Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations. Results In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012–2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%. Conclusions The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2330-1619/homepage/mdc312615-sup-v001.htm http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2330-1619/homepage/mdc312615-sup-v002.htm
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1cac4b951ac87add4922a55404cbe2e4 https://pubmed.ncbi.nlm.nih.gov/29984260 Zobrazit plný text záznamu Plný text ve formátu PDF