Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort

Autor: Carrière, Isabelle, Norton, Joanna, Farré, Amandine, Wyart, Marilyn, Tzourio, Christophe, Noize, Pernelle, Pérès, Karine, Fourrier-Réglat, Annie, Ritchie, Karen, Ancelin, Marie Laure
Přispěvatelé: Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de Psychiatrie [Nîmes], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie Clinique [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin [Bordeaux], Centre For Clinical Brain Sciences - Neuroimaging Sciences [Edinburgh, U.K.] (CCBS), University of Edinburgh, The 3C Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (Inserm), Victor-Segalen Bordeaux II University, and Sanofi-Aventis. The 3C-Study was also supported by the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, Direction Générale de la Santé, MGEN, the Institut de la Longévité, Agence Française de Sécurité Sanitaire des Produits de Santé, the Regional Governments of Aquitaine, Bourgogne and Languedoc-Roussillon, the Fondation de France, the Ministry of Research-Inserm Programme ‘Cohorts and collection of biological material’, Novartis and the Fondation Plan Alzheimer. This work was supported by the Fondation pour la Recherche Médicale under the program ‘Iatrogénie des Médicaments’, project ‘ELIANE-DEP–IMD20131229108’., BMC, BMC, Groupe hospitalier Pellegrin [Bordeaux] -CHU Bordeaux [Bordeaux]
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: BMC Medicine
BMC Medicine, 2016, 15 (1), pp.81. ⟨10.1186/s12916-017-0847-z⟩
BMC Medicine, BioMed Central, 2016, 15 (1), pp.81. ⟨10.1186/s12916-017-0847-z⟩
BMC Medicine, Vol 15, Iss 1, Pp 1-9 (2017)
ISSN: 1741-7015
Popis: Background Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. Methods The community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up. Treatment groups included participants under a specific antidepressant class at both baseline and the first follow-up and their follow-up cognitive data were considered until the last consecutive follow-up with a report of antidepressant use of the same class. Linear mixed models were used to compare baseline cognitive performance and cognitive decline over time according to antidepressant treatment. The models were adjusted for multiple confounders including residual depressive symptoms assessed by the Center for Epidemiologic Studies-Depression scale. Results At baseline, 4.0% of participants were taking antidepressants. Compared to non-users, tricyclic antidepressant users had lower baseline performances in verbal fluency, visual memory and psychomotor speed, and selective serotonin reuptake inhibitor users in verbal fluency and psychomotor speed. For the two other cognitive abilities, executive function and global cognition, no significant differences were found at baseline irrespective of the antidepressant class. Regarding changes over time, no significant differences were observed in comparison with non-users whatever the cognitive domain, except for a slight additional improvement over the follow-up in verbal fluency skills for tricyclic antidepressant users. Conclusions In this large elderly general population cohort, we found no evidence for an association between antidepressant use and post-treatment cognitive decline over 10 years of follow-up in various cognitive domains. Electronic supplementary material The online version of this article (doi:10.1186/s12916-017-0847-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
Externí odkaz: