Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
| Autor: | Valent, P., Akin, C., Hartmann, K., Nilsson, G., Reiter, A., Hermine, O., Sotlar, K., Sperr, W. R., Escribano, L., George, T. I., Kluin-Nelemans, H. C., Ustun, C., Triggiani, M., Brockow, K., Gotlib, J., Orfao, A., Kovanen, P. T., Hadzijusufovic, E., Sadovnik, I., Horny, H. -P., Arock, M., Schwartz, L. B., Frank Austen, K., Metcalfe, D. D., Galli, S. J. |
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| Přispěvatelé: | Austrian Science Fund, National Institutes of Health (US), United States-Israel Binational Science Foundation, Stanford University |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
mastocytosis
tryptase KIT Cell Differentiation History 19th Century Review History 20th Century histamine History 21st Century humanities Immunity Innate Disease Models Animal Histamine IgE receptor Mast cell activation Mastocytosis Tryptase Allergy and Immunology mast cell activation Hypersensitivity Animals Humans Mast Cells Molecular Targeted Therapy Precision Medicine Immunosuppressive Agents |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| Popis: | © The author(s). The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the origin, phenotypes and functions of MCs has increased substantially over the past 50 years. MCs are now known to be derived from multipotent hematopoietic progenitors, which, through a process of differentiation and maturation, form a unique hematopoietic lineage residing in multiple organs. In particular, MCs are distinguishable from basophils and other hematopoietic cells by their unique phenotype, origin(s), and spectrum of functions, both in innate and adaptive immune responses and in other settings. The concept of a unique MC lineage is further supported by the development of a distinct group of neoplasms, collectively referred to as mastocytosis, in which MC precursors expand as clonal cells. The clinical consequences of the expansion and/or activation of MCs are best established in mastocytosis and in allergic inflammation. However, MCs have also been implicated as important participants in a number of additional pathologic conditions and physiological processes. In this article, we review concepts regarding MC development, factors controlling MC expansion and activation, and some of the fundamental roles MCs may play in both health and disease. We also discuss new concepts for suppressing MC expansion and/or activation using molecularly-targeted drugs. P.V. was supported by the Austrian Science Fund (FWF), grants F4701-B28, F4704-B28 and P32470-B. DDM is supported by the Division of Intramural Research, NIAID. SJG's research is supported by the NIH, USA, the US-Israel Binational Foundation, and the Department of Pathology and the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA. |
| Databáze: | OpenAIRE |
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