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Nauman Hashmani, Maria Hashmani, Noureen Asghar, Mahnoor Islam, Sharif Hashmani Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, PakistanCorrespondence: Nauman Hashmani 68/B Khayaban-e-Shahbaz, DHA Phase 7, Karachi, PakistanTel +92 321-2828062Email naumanhashmani@hashmanis.edu.pkPurpose: To quantify and assess the reproducibility of the corneal stromal thickness profiles captured by the SD-OCT. Secondly, we correlated the zonal thicknesses to the age, gender and axial length.Methods: We included 227 normal eyes of 227 patients with a maximum hypermetropia of +5 and myopia of – 6 diopters (D). Subjects with an intraocular pressure exceeding 22 mm Hg, evidence of cataract formation, history of ophthalmic surgery or disease were excluded. Lastly, reproducibility was evaluated in a subset of 50 participants by means of an identical scan protocol repeated by 2 different OCT operators.Results: Stromal values were consistently thicker in the peripheral cornea (p< 0.001). Age was negatively correlated with approximately every sector of the stroma with notable exceptions of the center (r=0.117, p=0.088) and the superior inner (r=0.057, 0.409), middle (r=0.086, p=0.209) and outer locations (r=0.120, p=0.079). There was no statistical significance in most sectors when looking at the axial length, gender and K1/K2. This method was highly reproducible in terms of both the ICC and COV.Conclusion: Corneal stromal mapping is highly reproducible and shows a negative correlation to age. Additionally, the periphery of the stroma is consistently thicker to the center. Other variables like gender and axial length show no relationship to the corneal stroma.Keywords: cornea, corneal stroma, OCT, AS-OCT, tomography, topography |
