Magnetic resonance imaging of the ear for patient-specific reconstructive surgery

Autor: Nimeskern, Luc, Feldmann, Eva-Maria, Kuo, Willy, Schwarz, Silke, Goldberg-Bockhorn, Eva, Dürr, Susanne, Müller, Ralph, Rotter, Nicole, Stok, Kathryn S.
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Imaging Techniques
Brain Morphometry
Biomedical Engineering
lcsh:Medicine
Bioengineering
Otology
Image Analysis
Research and Analysis Methods
Diagnostic Radiology
Diagnostic Medicine
Medicine and Health Sciences
Humans
ddc:610
lcsh:Science
Tomography
Medical sciences
medicine
KERNSPINRESONANZ-ABBILDUNGSVERFAHREN + KERNSPINRESONANZ-TOMOGRAPHIE (MEDIZINISCHE DIAGNOSTIK)
OHREN
HÖR- UND GLEICHGEWICHTSORGANE (ANATOMIE UND PHYSIOLOGIE)
PLASTISCHE CHIRURGIE + REKONSTRUKTIVE CHIRURGIE
NUCLEAR MAGNETIC RESONANCE IMAGING + NUCLEAR MAGNETIC RESONANCE TOMOGRAPHY (MEDICAL DIAGNOSTICS)
EARS
ORGANS OF EQUILIBRIUM AND HEARING (ANATOMY AND PHYSIOLOGY)
PLASTIC SURGERY + RECONSTRUCTIVE SURGERY
Brain Mapping
Tissue Engineering
Radiology and Imaging
Morphometry
lcsh:R
Biology and Life Sciences
Ear
X-Ray Microtomography
Plastic Surgery Procedures
Magnetic Resonance Imaging
Otorhinolaryngology
Engineering and Technology
lcsh:Q
Ear Cartilage
Voxel-Based Morphometry
Research Article
Biotechnology
Neuroscience
Zdroj: PLoS ONE, 9 (8)
PLoS ONE, Vol 9, Iss 8, p e104975 (2014)
PLoS ONE
Popis: INTRODUCTION: Like a fingerprint, ear shape is a unique personal feature that should be reconstructed with a high fidelity during reconstructive surgery. Ear cartilage tissue engineering (TE) advantageously offers the possibility to use novel 3D manufacturing techniques to reconstruct the ear, thus allowing for a detailed auricular shape. However it also requires detailed patient-specific images of the 3D cartilage structures of the patient's intact contralateral ear (if available). Therefore the aim of this study was to develop and evaluate an imaging strategy for acquiring patient-specific ear cartilage shape, with sufficient precision and accuracy for use in a clinical setting. METHODS AND MATERIALS: Magnetic resonance imaging (MRI) was performed on 14 volunteer and six cadaveric auricles and manually segmented. Reproducibility of cartilage volume (Cg.V), surface (Cg.S) and thickness (Cg.Th) was assessed, to determine whether raters could repeatedly define the same volume of interest. Additionally, six cadaveric auricles were harvested, scanned and segmented using the same procedure, then dissected and scanned using high resolution micro-CT. Correlation between MR and micro-CT measurements was assessed to determine accuracy. RESULTS: Good inter- and intra-rater reproducibility was observed (precision errors 0.82), but low for Cg.Th (0.95) demonstrated high accuracy. DISCUSSION AND CONCLUSION: This study demonstrated that precision and accuracy of the proposed method was high enough to detect patient-specific variation in ear cartilage geometry. The present study provides a clinical strategy to access the necessary information required for the production of 3D ear scaffolds for TE purposes, including detailed patient-specific shape. Furthermore, the protocol is applicable in daily clinical practice with existing infrastructure.
Databáze: OpenAIRE
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