Studies on the antigenic determinants of the Thy-1.2 alloantigen as expressed by the murine lymphoblastoid line S-49.1 TB-2-3

Autor:	Bj, Johnson, Un, Kucich, Anthony Maurelli
Rok vydání:	1976
Předmět:	Epitopes Isoantigens Mice Sialic Acids Animals Thymus Gland In Vitro Techniques Cytotoxicity Tests Immunologic Cell Line
Zdroj:	Europe PubMed Central
ISSN:	0022-1767
Popis:	Sialic acid has been shown to be part of the antigenic determinant of the Thy-1.2 alloantigen as expressed by the murine cell line S-49.1 TB-2-3 (S-49). This conclusion is based on the loss of cytotoxic inhibitory activity by the action of neuraminidase on the Thy-1.2 alloantigen. Also, sialic acid has the ability to inhibit the cytotoxic assay of AKR anti-C3H Thy-1.2 serum for S-49 cells. Further evidence for the protein nature of the Thy-1.2 alloantigen is apparent by trypsin digestion. Possibly the Thy-1.2 alloantigen as expressed on S-49 cells is a glycoprotein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::196d67c5d8d89ab9907dff5798c6a360 https://pubmed.ncbi.nlm.nih.gov/58044 Zobrazit plný text záznamu