A study of neural activity and functional connectivity within the olfactory brain network in Parkinsons disease

Autor: Charalampos Georgiopoulos, Suzanne T. Witt, Sven Haller, Nil Dizdar, Helene Zachrisson, Maria Engström, Elna-Marie Larsson
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
FLAIR
Fluid Attenuated Inversion Recovery
UPDRS
Unified Parkinson's Disease Rating Scale
Olfactory Perception/physiology
FIR
Finite Impulse Response
MNI
Montreal Neurological Institute
lcsh:Computer applications to medicine. Medical informatics
EPI
Echo planar imaging
MMSE
Mini-Mental State Examination
PD
Parkinson's disease
lcsh:RC346-429
Parkinson Disease/diagnostic imaging/physiopathology
Functional connectivity
Connectome
Humans
Parkinson
DaTSCAN
SPECT with the presynaptic ligand ioflupane
lcsh:Neurology. Diseases of the nervous system
Aged
GLM
General Linear Model
TE
echo time
Cerebral Cortex
FWHM
Full Width Half Maximum
fMRI
Cerebral Cortex/diagnostic imaging/physiopathology
fMRI
functional Magnetic Resonance Imaging
Neurosciences
Nerve Net/diagnostic imaging/physiopathology
Regular Article
Parkinson Disease
Middle Aged
Olfactory Perception
Olfaction
Magnetic Resonance Imaging
TR
repetition time
UPSIT
University of Pennsylvania Smell Identification Test
BOLD
Blood Oxygen Level Dependent
H&Y
Hoehn and Yahr Staging
ICA
Independent Component Analysis
lcsh:R858-859.7
FDR
False discovery rate
SPECT
Single Photon Emission Computed Tomography
Female
Nerve Net
CI
Confidence Intervals
Neurovetenskaper
Zdroj: NeuroImage: Clinical, Vol. 23 (2019) P. 101946
NeuroImage : Clinical
NeuroImage: Clinical, Vol 23, Iss, Pp-(2019)
ISSN: 2213-1582
Popis: Olfactory dysfunction is an early manifestation of Parkinson's disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls in terms of neural activity and functional connectivity within the olfactory brain network. Twenty PD patients and twenty healthy controls were examined with olfactory fMRI and resting-state fMRI. Data analysis of olfactory fMRI included data-driven tensorial independent component (ICA) and task-driven general linear model (GLM) analyses. Data analysis of resting-state fMRI included probabilistic ICA based on temporal concatenation and functional connectivity analysis within the olfactory network. ICA of olfactory fMRI identified an olfactory network consisting of the posterior piriform cortex, insula, right orbitofrontal cortex and thalamus. Recruitment of this network was less significant for PD patients. GLM analysis revealed significantly lower activity in the insula bilaterally and the right orbitofrontal cortex in PD compared to healthy controls but no significant differences in the olfactory cortex itself. Analysis of resting-state fMRI did not reveal any differences in the functional connectivity within the olfactory, default mode, salience or central executive networks between the two groups. In conclusion, olfactory dysfunction in PD is associated with less significant recruitment of the olfactory brain network. ICA could demonstrate differences in both the olfactory cortex and its main projections, compared to GLM that revealed differences only on the latter. Resting-state fMRI did not reveal any significant differences in functional connectivity within the olfactory, default mode, salience and central executive networks in this cohort.
Highlights • Less significant recruitment of the olfactory brain network was found in Parkinson's disease. • Independent component analysis reveals differences in both olfactory cortex and its projections. • Differences in functional connectivity within the olfactory network were not significant.
Databáze: OpenAIRE
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