Lateral fluid-percussion injury leads to pituitary atrophy in rats
| Autor: | Mehwish Anwer, Riikka Immonen, Nick M. E. A. Hayward, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Olli Gröhn, Asla Pitkänen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Epilepsy lcsh:R lcsh:Medicine Convulsants Electroencephalography Prognosis Magnetic Resonance Imaging Article nervous system diseases Rats Experimental models of disease Disease Models Animal Prognostic markers nervous system Pituitary Gland Brain Injuries Traumatic Animals Humans Pentylenetetrazole lcsh:Q lcsh:Science Maze Learning Retrospective Studies |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Traumatic brain injury (TBI) causes neuroendocrine dysregulation in up to 40% of humans, which is related to impaired function of the hypothalamo-hypophyseal axis and contributes to TBI-related co-morbidities. Our objective was to investigate whether hypophyseal atrophy can be recapitulated in rat lateral fluid-percussion injury model of human TBI. High-resolution structural magnetic resonance images (MRI) were acquired from rats at 2 days and 5 months post-TBI. To measure the lobe-specific volumetric changes, manganese-enhanced MRI (MEMRI) scans were acquired from rats at 8 months post-TBI, which also underwent the pentylenetetrazol (PTZ) seizure susceptibility and Morris water-maze spatial memory tests. MRI revealed no differences in the total hypophyseal volume between TBI and controls at 2 days, 5 months or 8 months post-TBI. Surprisingly, MEMRI at 8 months post-TBI indicated a 17% reduction in neurohypophyseal volume in the TBI group as compared to controls (1.04 ± 0.05 mm3 vs 1.25 ± 0.05 mm3, p |
| Databáze: | OpenAIRE |
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