Proteomic data on the nuclear interactome of human MCM9
| Autor: | Hutchins, James R.A., Traver, Sabine, Coulombe, Philippe, Peiffer, Isabelle, Kitzmann, Magali, Latreille, Daniel, Méchali, Marcel |
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| Přispěvatelé: | Institut de génétique humaine ( IGH ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Développement embryonnaire précoce humain et pluripotence EmbryoPluripotency (UMR 1203), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-CHU Montpellier |
| Rok vydání: | 2016 |
| Předmět: |
[SDV.GEN]Life Sciences [q-bio]/Genetics
[SDV]Life Sciences [q-bio] Proteomics Data lcsh:Computer applications to medicine. Medical informatics DNA Replication And Repair Mass Spectrometry Protein-Protein Interactions Affinity Purification lcsh:R858-859.7 lcsh:Science (General) [ SDV.GEN ] Life Sciences [q-bio]/Genetics ComputingMilieux_MISCELLANEOUS Data Article lcsh:Q1-390 |
| Zdroj: | Data in Brief Data in Brief, Elsevier, 2015, 6, pp.410-415 Data in Brief, Elsevier, 2015, 6, pp.410-415. ⟨10.1016/j.dib.2015.11.055⟩ Data in Brief, Vol 6, Iss, Pp 410-415 (2016) Data in Brief, Elsevier, 2016, 6, pp.410-415. ⟨10.1016/j.dib.2015.11.055⟩ |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2015.11.055 |
| Popis: | We present data relating to the interactome of MCM9 from the nuclei of human cells. MCM9 belongs to the AAA+ superfamily, and contains an MCM domain and motifs that may confer DNA helicase activity. MCM9 has been shown to bind MCM8, and has been implicated in DNA replication and homologous recombination. However, the mechanistic basis of MCM9’s role in DNA repair is poorly understood, and proteins with which it interacts were hitherto unknown. We performed tandem affinity purification of MCM9 and its interacting proteins from nuclear extracts of human cells, followed by proteomic analysis, thereby generating a set of mass spectrometry data corresponding to the MCM9 interactome [1]. The proteomic data set comprises 29 mass spectrometry RAW files, deposited to the ProteomeXchange Consortium, and freely available from the PRIDE partner repository with the data set identifier http://www.ebi.ac.uk/pride/archive/projects/PXD000212. A set of 22 interacting proteins identified from the proteomic data was used to create an MCM9-centered interactive network diagram, using the Cytoscape program. These data allow the scientific community to access, mine and explore the human nuclear MCM9 interactome. Keywords: Proteomics Data, Mass Spectrometry, DNA Replication And Repair, Affinity Purification, Protein-Protein Interactions |
| Databáze: | OpenAIRE |
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