[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines]

Autor:	Fs, Mikhaĭlitsyn, Felix Kovalenko, Np, Kozyreva, Vi, Dzhabarova, Mn, Lebedeva, Nd, Lychko, As, Naĭdenova, Na, Uvarova
Rok vydání:	1994
Předmět:	Male Mebendazole Mice Hymenolepiasis Echinococcosis Drug Evaluation Preclinical Quinolines Animals Anticestodal Agents Niclosamide Female Sigmodontinae
Zdroj:	Europe PubMed Central
ISSN:	0025-8326
Popis:	The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16e84c4d58e83494efb8b4157592d39a https://pubmed.ncbi.nlm.nih.gov/7799857 Zobrazit plný text záznamu