[The characteristics of catecholamine metabolism in patients in the initial stage of hypertension]

Autor: Vi, Makolkin, Valery Podzolkov, Td, Bol Shakova
Rok vydání: 1997
Předmět:
Zdroj: Europe PubMed Central
ISSN: 0040-3660
Popis: Catecholamines metabolism (24-h excretion, circadian rhythm of DOPA, dopamine, homovanillic acid, adrenaline, noradrenaline, vanilmandelic acid) was investigated in 124 young males with stage I essential hypertension treated by cranial electrostimulation. Relative activity of this metabolism stages was assessed. Patients with early stages of essential hypertension seem to have enhanced secretory and metabolic activity of the sympathetic link of the sympathoadrenal system with associated dopamine dysbolism; relative deficiency of dopaminergic system with activation of dopamine conversion to homovanillic acid in its intact conjugation. It is suggested that a marked increase of the ratio noradrenaline/dopamine may serve a biochemical marker of essential hypertension and risk of the disease progression.
Databáze: OpenAIRE