Brain structural changes in women and men during midlife
| Autor: | Guo, J.Y., Isohanni, M., Miettunen, J., Jääskeläinen, E., Kiviniemi, V., Nikkinen, J., Remes, J., Huhtaniska, S., Veijola, J., Jones, P.B., Murray, G.K. |
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| Přispěvatelé: | Jones, Peter [0000-0002-0387-880X], Murray, Graham [0000-0001-8296-1742], Apollo - University of Cambridge Repository |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male FSL FMRIB software library Neuroscience(all) TFCE threshold-free cluster enhancement SIENA structural image evaluation using normalisation CSF cerebrospinal fluid Cohort Studies Sexual dimorphism Sex Factors Sex differences NFBC 1966 Northern Finland Birth Cohort 1966 Gender difference Humans WM white matter FLIRT FMRIB's linear image registration tool PBVC percentage brain volume change Age Factors Brain GM grey matter Organ Size Magnetic Resonance Imaging Ageing Longitudinal MRI Female FAST FMRIB's automated segmentation tool Research Paper |
| Zdroj: | Neuroscience Letters |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2016.01.007 |
| Popis: | Highlights • Women lost more total brain volume than men during 8.5 years follow-up in midlife. • Women showed greater brain reduction in bilateral brain regions with and without co-varying for total brain volume loss. • Men exhibited greater brain reduction in mid-line brain regions after correcting for the total brain volume loss. Brain development during childhood and adolescence differs between boys and girls. Structural changes continue during adulthood and old age, particularly in terms of brain volume reductions that accelerate beyond age 35 years. We investigated whether brain structural change in mid-life differs between men and women. 43 men and 28 women from the Northern Finland 1966 Birth Cohort underwent MRI brain scans at age 33–35 (SD = 0.67) and then again at age 42–44 (SD = 0.41). We examined sex differences in total percentage brain volume change (PBVC) and regional brain change with FSL SIENA software. Women showed significant PBVC reduction compared with men between the ages of 33–35 and 42–44 years (Mean = −3.21% in men, Mean = −4.03% in women, F (1, 68) = 6.37, p |
| Databáze: | OpenAIRE |
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