Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity
| Autor: | Dragon-Durey, Marie-Agnès, Chen, Xiaoyi, Kirilovsky, Amos, Ben Hamouda, Nadine, El Sissy, Carine, Russick, Jules, Charpentier, Etienne, Binois, Yannick, Marliot, Florence, Meylan, Maxime, Granier, Clémence, Pere, Hélène, Saldmann, Antonin, Rance, Bastien, Jannot, Anne Sophie, Baron, Stéphanie, Chebbi, Mouna, Fayol, Antoine, Josseaume, Nathalie, Rives-Lange, Claire, Tharaux, Pierre-Louis, Cholley, Bernard, Diehl, Jean-Luc, Arlet, Jean-Benoît, Azizi, Michel, Karras, Alexandre, Czernichow, Sébastien, Smadja, David M., Hulot, Jean-Sébastien, Cremer, Isabelle, Tartour, Eric, Mousseaux, Elie, Pagès, Franck |
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| Přispěvatelé: | Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
Male Viral Diseases Physiology Coronaviruses [SDV]Life Sciences [q-bio] Severity of Illness Index Body Mass Index Diagnostic Radiology Medical Conditions Immune Physiology Medicine and Health Sciences Prospective Studies Immune Response Tomography Lung Pathology and laboratory medicine Virus Testing Innate Immune System Radiology and Imaging Medical microbiology Middle Aged Hospitalization Intensive Care Units Infectious Diseases Physiological Parameters Liver Viruses Cytokines RNA Viral Medicine Female SARS CoV 2 Pathogens Chemokines Research Article SARS coronavirus Imaging Techniques Science Immunology Neuroimaging Research and Analysis Methods Microbiology Signs and Symptoms Diagnostic Medicine Humans Obesity Aged Inflammation SARS-CoV-2 Body Weight Organisms Viral pathogens Biology and Life Sciences COVID-19 Covid 19 Molecular Development Microbial pathogens Computed Axial Tomography Immune System Endothelium Vascular Clinical Medicine Biomarkers Developmental Biology Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2021, 16 (5), pp.e0252026. ⟨10.1371/journal.pone.0252026⟩ PLoS ONE, Vol 16, Iss 5, p e0252026 (2021) |
| ISSN: | 1932-6203 |
| Popis: | International audience; To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications. |
| Databáze: | OpenAIRE |
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