Detection of IgA heavy chain constant region genes in IgA deficient donors: evidence against gene deletions

Autor:	Hammarström L, Carlsson B, Ci, Smith, Wallin J, Lars Wieslander
Předmět:	Genes MHC Class II IgA Deficiency Immunoglobulins DNA DNA Restriction Enzymes Immunoglobulin A Molecular Weight Humans Dysgammaglobulinemia Lymphocytes Chromosome Deletion Immunoglobulin Constant Regions Immunoglobulin Heavy Chains Research Article
Zdroj:	Europe PubMed Central
Popis:	Sixty-six donors with selective IgA deficiency and one patient with selective IgA2 deficiency were investigated for immunoglobulin gene defects using restriction enzyme digestions and Southern blot analysis. All patients carried alpha 1 and alpha 2 genes in their genome, suggesting that large deletions are uncommon causes for IgA deficiency. Digestion with Bam HI, Pst I and Pvu II, did not reveal any polymorphism in the studied samples.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15de0344d96fcd70472082395b3430c2 http://europepmc.org/abstract/med/2990782 Zobrazit plný text záznamu