Natural lecithin promotes neural network complexity and activity
| Autor: | Latifi, Shahrzad, Tamayol, Ali, Habibey, Rouhollah, Sabzevari, Reza, Kahn, Cyril, Geny, David, Eftekharpour, Eftekhar, Annabi, Nasim, Blau, Axel, Linder, Michel, Arab-Tehrany, Elmira |
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| Přispěvatelé: | Istituto Italiano di Tecnologia (IIT), Department of Neurology [UCLA], University of California [Los Angeles] (UCLA), University of California-University of California-David Geffen School of Medicine [Los Angeles], University of California-University of California, University of Manitoba [Winnipeg], Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Robotics and perception group [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Northeastern University [Boston], Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), University of Zürich [Zürich] (UZH), Aix Marseille Université (AMU)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), University of California (UC)-University of California (UC)-David Geffen School of Medicine [Los Angeles], University of California (UC)-University of California (UC), Centre de Psychiatrie et Neurosciences (U894) |
| Rok vydání: | 2016 |
| Předmět: |
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
MESH: Synapsins/genetics Synapsins/metabolism [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Messenger MESH: Mitochondria/drug effects Mitochondria/metabolism Article MESH: Animal Complementary and Alternative Medicine Lecithins Complementary and Integrative Health Animals RNA Messenger [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics Neurons Neurosciences MESH: Nanoparticles/chemistry Nanoparticles/ultrastructure Synapsins MESH: Neurons/drug effects Neurons/metabolism Mitochondria Rats Other Physical Sciences Liposomes Neurological RNA Nanoparticles lipids (amino acids peptides and proteins) [SDV.IB]Life Sciences [q-bio]/Bioengineering Biochemistry and Cell Biology Nerve Net MESH: Lecithins/pharmacology* Liposomes Microelectrodes |
| Zdroj: | Scientific reports, vol 6, iss 1 Scientific Reports Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep25777⟩ Latifi, S; Tamayol, A; Habibey, R; Sabzevari, R; Kahn, C; Geny, D; et al.(2016). Natural lecithin promotes neural network complexity and activity. SCIENTIFIC REPORTS, 6. doi: 10.1038/srep25777. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7tc5n297 Scientific Reports, 2016, 6 (1), ⟨10.1038/srep25777⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep25777⟩ |
| Popis: | International audience; Phospholipids in the brain cell membranes contain different polyunsaturated fatty acids (PUFAs), which are critical to nervous system function and structure. In particular, brain function critically depends on the uptake of the so-called "essential" fatty acids such as omega-3 (n-3) and omega-6 (n-6) PUFAs that cannot be readily synthesized by the human body. We extracted natural lecithin rich in various PUFAs from a marine source and transformed it into nanoliposomes. These nanoliposomes increased neurite outgrowth, network complexity and neural activity of cortical rat neurons in vitro. We also observed an upregulation of synapsin I (SYN1), which supports the positive role of lecithin in synaptogenesis, synaptic development and maturation. These findings suggest that lecithin nanoliposomes enhance neuronal development, which may have an impact on devising new lecithin delivery strategies for therapeutic applications. |
| Databáze: | OpenAIRE |
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