Congenital ureteropelvic junction obstruction: human disease and animal models

Autor: Klein, Julie, Gonzalez, Julien, Miravete, Mathieu, Caubet, Cécile, Chaaya, Rana, Decramer, Stéphane, Bandin, Flavio, Bascands, Jean-Loup, Buffin-Meyer, Bénédicte, Schanstra, Joost
Přispěvatelé: Simon, Marie Francoise, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pédiatrie - Néphrologie, Médecine interne, Hypertension, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Rok vydání: 2010
Předmět:
Zdroj: International Journal of Experimental Pathology
International Journal of Experimental Pathology, 2010, epub ahead of print. ⟨10.1111/j.1365-2613.2010.00727.x⟩
ISSN: 1365-2613
0959-9673
Popis: International audience; Summary Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology and function and describe the molecular mechanisms involved in the progression of the lesions, including inflammation, proliferation/apoptosis, renin-angiotensin system activation and fibrosis, based on both human and animal data. Also we propose that during obstructive nephropathy, hydrodynamic modifications are early inducers of the tubular lesions, which are potentially at the origin of the pathology. Finally, an important observation in animal models is that relief of obstruction during kidney development has important effects on renal function later in adult life. A major short-coming is the absence of data on the impact of UPJ obstruction on long-term adult renal function to elucidate whether these animal data are also valid in humans.
Databáze: OpenAIRE
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