Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
| Autor: | Annese, Valentina, Barcia, C., Ros Bernal, F., Gomez, A., Ros, C. m., De Pablos, V., Fernánzez Villalba, E., DE STEFANO, Maria Egle, Herrero, M. t. |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
glial response parkinson’s disease Dopaminergic Neurons neurodegeneration oligodendrocytes mptp Mice Inbred C57BL Neostriatum Substantia Nigra Disease Models Animal Mice Oligodendroglia Parkinsonian Disorders nervous system 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine parkinson's disease Parkinson’s disease Animals Macaca MPTP |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I |
| Popis: | Aims: Mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) represent elective experimental models of Parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway is associated with prominent neuroinflammation, characterized by activated microglia and astrocytes in both substantia nigra (SN) and striatum. To date, it is unknown whether oligodendrocytes play a role in these events. Methods: We performed a detailed qualitative and quantitative analysis of oligodendrocyte-associated changes induced by acute and chronic MPTP treatment, in the SN and striatum of mice and macaques respectively. Oligodendrocytes were immunolabelled by cell-specific markers and analysed by confocal microscopy. Results: In both experimental models, MPTP treatment induces an increase in oligodendrocyte cell number and average size, as well as in the total area occupied by this cell type per tissue section, accompanied by evident morphological changes. This multifaceted array of changes, herein referred to as oligodendrogliosis, significantly correlates with the reduction in the level of dopaminergic innervation to the striatum. Conclusions: This event, associated with early damage of the dopaminergic neurone axons and of the complex striatal circuits of which they are part, may result in an important, although neglected, aspect in the onset and progression of Parkinsonism. |
| Databáze: | OpenAIRE |
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