Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome

Autor:	Moti, M., Leila Amini, Ardakani, S. S. M., Kamalzadeh, S., Masoomikarimi, M., Jafarisani, M.
Předmět:	lcsh:QH471-489 endocrine system diseases Short Communication Infertility AOPP lcsh:Reproduction nutritional and metabolic diseases Antioxidant CRP lcsh:Gynecology and obstetrics lcsh:RG1-991 female genital diseases and pregnancy complications Polycystic ovary syndrome
Zdroj:	Web of Science Iranian Journal of Reproductive Medicine Scopus-Elsevier Iranian Journal of Reproductive Medicine, Vol 13, Iss 6, Pp 373-378 (2015)
Popis:	Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples. Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1458f8dd4746365edb6f1167f9af288b https://publons.com/wos-op/publon/33517870/ Zobrazit plný text záznamu