The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study
| Autor: | Hovingh, G. Kees, Smits, Loek P., Stefanutti, Claudia, Soran, Handrean, Kwok, See, de Graaf, Jacqueline, Gaudet, Daniel, Keyserling, Constance H., Klepp, Heather, Frick, Jennifer, Paolini, John F., Dasseux, Jean-Louis, Kastelein, John J. P., Stroes, Erik S. |
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| Přispěvatelé: | ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Graduate School |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Apolipoprotein A-I Medicine (all) Cholesterol LDL Coronary Artery Disease Middle Aged Female Humans Hyperlipoproteinemia Type II Lipids Phospholipids Rare Diseases Recombinant Proteins Carotid Intima-Media Thickness Cardiology and Cardiovascular Medicine LDL Cholesterol lipids (amino acids peptides and proteins) |
| Zdroj: | American heart journal, 169(5), 736-742.e1. Mosby Inc. |
| ISSN: | 0002-8703 |
| Popis: | Patients with homozygous familial hypercholesterolemia (HoFH) are at extremely elevated risk for early cardiovascular disease because of exposure to elevated low-density lipoprotein cholesterol (LDL-C) plasma levels from birth. Lowering LDL-C by statin therapy is the cornerstone for cardiovascular disease prevention, but the residual risk in HoFH remains high, emphasizing the need for additional therapies. In the present study, we evaluated the effect of serial infusions with CER-001, a recombinant human apolipoprotein A-I (apoA-I)-containing high-density lipoprotein-mimetic particle, on carotid artery wall dimensions in patients with HoFH. Twenty-three patients (mean age 39.4 ± 13.5 years, mean LDL-C 214.2 ± 81.5 mg/dL) with genetically confirmed homozygosity or compound heterozygosity for LDLR, APOB, PCSK9, or LDLRAP1 mutations received 12 biweekly infusions with CER-001 (8 mg/kg). Before and 1 hour after the first infusion, lipid values were measured. Magnetic resonance imaging (3-T magnetic resonance imaging) scans of the carotid arteries were acquired at baseline and after 24 weeks to assess changes in artery wall dimensions. After CER-001 infusion, apoA-I increased from 114.8 ± 20.7 mg/dL to 129.3 ± 23.0 mg/dL. After 24 weeks, mean vessel wall area (primary end point) decreased from 17.23 to 16.75 mm(2) (P = .008). A trend toward reduction of mean vessel wall thickness was observed (0.75 mm at baseline and 0.74 mm at follow-up, P = .0835). In HoFH, 12 biweekly infusions with an apoA-I-containing high-density lipoprotein-mimetic particle resulted in a significant reduction in carotid mean vessel wall area, implying that CER-001 may reverse atherogenic changes in the arterial wall on top of maximal low-density lipoprotein-lowering therapy. This finding supports further clinical evaluation of apoA-I-containing particles in patients with HoFH |
| Databáze: | OpenAIRE |
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