Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD
| Autor: | Himmerich, Hubertus, Willmund, Gerd D, Zimmermann, Peter, Wolf, Jörg-Egbert, Bühler, Antje H, Kirkby, Kenneth C, Dalton, Bethan, Holdt, Lesca M., Teupser, Daniel, Wesemann, Ulrich |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Combat Disorders Post-traumatic stress disorder Tumor Necrosis Factor-alpha Soluble TNF receptors Middle Aged Combined Modality Therapy Antidepressive Agents Psychotherapy Stress Disorders Post-Traumatic Cross-Sectional Studies Military Personnel Patient Admission Receptors Tumor Necrosis Factor Type I Materia Medica Tumor necrosis factor (TNF-α) Ambulatory Care Cytokines Humans sense organs Longitudinal Studies skin and connective tissue diseases cytokines - tumor necrosis factor (TNF-a) - soluble TNF receptors - post-traumatic stress disorder - psychotherapy |
| Zdroj: | Psychiatria Danubina Volume 28 Issue 3 Himmerich, H, Willmund, G D, Zimmermann, P, Wolf, J-E, Bühler, A H, Kirkby, K C, Dalton, B, Holdt, L M, Teupser, D & Wesemann, U 2016, ' Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD ', Psychiatria Danubina, vol. 28, no. 3, pp. 293-298 . < http://www.hdbp.org/psychiatria_danubina/2016_Vol_28_No_3.html?ver=1.1 > |
| ISSN: | 0353-5053 |
| Popis: | BACKGROUND: Changes in serum concentrations of tumor necrosis factor-α (TNF-α) and its soluble receptors (sTNF-R) p55 and p75 have been shown to be associated with various psychiatric treatments.SUBJECTS AND METHODS: Before and after treatment, serum levels of TNF-α, sTNF-R p55 and sTNF-R p75 were measured in 38 German soldiers who had been deployed abroad and suffered from combat-related post-traumatic stress disorder (PTSD). Patients were randomized either to inpatient psychotherapy (N=21) including eye movement desensitization and reprocessing (EMDR) or to outpatient clinical management (N=17). Symptoms of PTSD were measured using the Post-traumatic Stress Diagnostic Scale (PDS).RESULTS: The PDS score significantly decreased across time in both groups. Serum concentrations of TNF-α increased, while sTNF-R p55 and sTNF-R p75 levels decreased significantly. After the treatment period, we could not detect any significant difference regarding TNF-α, sTNF-R p55 or sTNF-R p75 levels between the inpatient psychotherapy group and the outpatient clinical management control group.CONCLUSIONS: This relatively small clinical study suggests that specific inpatient psychotherapy but also non-specific supportive outpatient treatment for PTSD are associated with changes in the TNF-α system. This may represent an immunological effects or side effects of psychotherapy. |
| Databáze: | OpenAIRE |
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