[Effect oh millimeter waves on the immune system in mice with experimental tumors]
| Autor: | Eg, Novoselova, Vb, Ogaĭ, Oa, Sinotova, Olga Glushkova, Ov, Sorokina, Ee, Fesenko |
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| Předmět: |
Male
B-Lymphocytes Immunity Cellular Mice Inbred BALB C Time Factors Tumor Necrosis Factor-alpha T-Lymphocytes Lymphocyte Activation Nitric Oxide Killer Cells Natural Mice Electromagnetic Fields Animals Interleukin-2 Interleukin-3 Carcinoma Ehrlich Tumor Cell Division Neoplasm Transplantation Spleen |
| Zdroj: | Europe PubMed Central |
| Popis: | The effect of low-level millimeter fractionated radiation on the production of tumor necrosis factor, intreleukin-2, interleukine-3, and nitric oxide and on the activity of natural killer cells and proliferation of T and B lymphocytes in mice was studied. Cell activity was measured in four groups of male Balb/c mice (control, exposed, tumor-bearing unexposed, and exposed tumor-bearing animals) within 30 days of tumoral growth and microwave exposure (42.2 GHz, 10 Hz amplitude modulation, 0.5 microW/cm2, 1.5 h daily). A significant increase in the production of tumor necrosis factor and nitric oxide and in the activity of natural killer cells was observed at the early stage of tumor development; this effect was considered as adaptive response. In healthy mice, millimeter radiation produced both stimulating and immunodepressive effects. The changes were nonmonotonous; as the exposure duration was increased, the stimulating effect became weaker and on day 30 it was not observed. Irradiation of tumor-bearing mice did not induce any significant changes in the activity of cells compared to unirradiated tumor-bearing animals. Moreover, exposure to millimeter waves impaired some characteristics of cell immunity in tumor-bearing mice. It was concluded that low-intensity millimeter waves do not increase the resistance against tumor as it was shown earlier in our experiments with centimeter waves. |
| Databáze: | OpenAIRE |
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