Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura
| Autor: | Pegueroles Queralt, Cinta, Ferrés Coy, Albert, Martí-Solano, Maria, Aquadro, Charles F., Pascual Berniola, Marta, Mestres i Naval, Francesc |
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| Přispěvatelé: | Ministerio de Ciencia y Tecnología (España), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular Genètica de poblacions Polymorphism Genetic Ecology RNA-Binding Proteins Plants Adaptation Physiological Article Ecologia Chromosomes Insect Fragile X Mental Retardation Protein Amino Acid Substitution Chromosome Inversion Genetics Animals Drosophila Proteins Drosophila Amino Acid Sequence Sodium-Potassium-Exchanging ATPase Carrier Proteins Ouabain Drosòfila Genètica Genètica Population Genetics Toxins Biological |
| Zdroj: | Scientific Reports Digital.CSIC. Repositorio Institucional del CSIC instname Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep23754 |
| Popis: | Adaptation is defined as an evolutionary process allowing organisms to succeed in certain habitats or conditions. Chromosomal inversions have the potential to be key in the adaptation processes, since they can contribute to the maintenance of favoured combinations of adaptive alleles through reduced recombination between individuals carrying different inversions. We have analysed six genes (Pif1A, Abi, Sqd, Yrt, Atpα and Fmr1), located inside and outside three inversions of the O chromosome in European populations of Drosophila subobscura. Genetic differentiation was significant between inversions despite extensive recombination inside inverted regions, irrespective of gene distance to the inversion breakpoints. Surprisingly, the highest level of genetic differentiation between arrangements was found for the Atpα gene, which is located outside the O and O inversions. Two derived unrelated arrangements (O and O) are nearly fixed for several amino acid substitutions at the Atpα gene that have been described to confer resistance in other species to the cardenolide ouabain, a plant toxin capable of blocking ATPases. Similarities in the Atpα variants, conferring ouabain resistance in both arrangements, may be the result of convergent substitution and be favoured in response to selective pressures presumably related to the presence of plants containing ouabain in the geographic locations where both inversions are present. This work was supported by a pre-doctoral fellowship to CP (2009FIC-00096) from the Generalitat de Catalunya (Spain). Research was funded by projects CGL2006-13423-C02-02 from the Ministerio de Ciencia y Tecnología (MCYT, Spain) and CTM2013-48163-C2-2-R from the Ministerio de Economía y Competitividad (MINECO, Spain). MP and FM are members of the research group 2014-SGR336 from the Generalitat de Catalunya (Spain). |
| Databáze: | OpenAIRE |
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