Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicenter-controlled study
| Autor: | G, Morgia, G, Mucciardi, A, Galì, M, Madonia, F, Marchese, A, Di Benedetto, G, Romano, G, Bonvissuto, T, Castelli, L, Macchione, C, Magno |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Time Factors Plant Extracts Anti-Inflammatory Agents Syndrome Middle Aged Prostate-Specific Antigen Urine Pelvic Pain Carotenoids Severity of Illness Index Prostatitis Drug Combinations Leukocyte Count Selenium Urodynamics Young Adult Lycopene Treatment Outcome Double-Blind Method Italy Serenoa Chronic Disease Humans |
| Popis: | To evaluate the efficacy and safety of Serenoa repens + selenium and lycopene (Profluss) versus S. repens alone for the treatment of category IIIa chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).102 patients with IIIa CP/CPPS were enrolled and randomized into two groups each to receive Profluss or S. repens alone for 8 weeks. Evaluation was based on results of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), IPSS, maximum peak flow rate (MPFR), and PSA measurements at baseline and at weeks 4, 8 and 8 after the end of treatment. The primary endpoint was a50% reduction in NIH-CPSI score. Secondary endpoints evaluated were MPFR, IPSS, PSA and white blood cell count.No patients withdrew from the study. The mean NIH-CPSI score decreased significantly (p0.001) in both groups; we observed a decrease in the total score from 27.45 to 13.27 in group 1 (-51.64%) and from 27.76 to 20.62 in group 2 (-26.06%). IPSS improved significantly (p0.001) in both arms, but more in group 1. PSA and white blood cell count decreased significantly (p0.007) only in group 1. The MPFR improved more in group 1 (p0.005).Profluss is a triple therapy that is safe and well tolerated. It ameliorates symptoms associated with IIIa CP/CPPS. |
| Databáze: | OpenAIRE |
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