Autoantibodies against BAFF, APRIL or IL21 - an alternative pathogenesis for antibody-deficiencies?
| Autor: | Marian-Christopher Pott, Natalie Frede, Jennifer Wanders, Lennart Hammarström, Erik-Oliver Glocker, Cristina Glocker, Fariba Tahami, Bodo Grimbacher |
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| Rok vydání: | 2016 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
STAT3 Transcription Factor Cell Survival Interleukins Tumor Necrosis Factor Ligand Superfamily Member 13 B-Lymphocyte Subsets IgA Deficiency Immunologic Deficiency Syndromes Autoimmunity Common variable immunodeficiency B-Cell Activating Factor Selective IgA deficiency IL-21 Humans Cytokines BAFF APRIL Phosphorylation lcsh:RC581-607 Primary antibody deficiency Autoantibodies Research Article |
| Zdroj: | BMC Immunology BMC Immunology, Vol 18, Iss 1, Pp 1-8 (2017) |
| ISSN: | 1471-2172 |
| Popis: | Background: The ability of anti-cytokine antibodies to play a disease-causing role in the pathogenesis of immunodeficiencies is widely accepted. The aim of this study was to investigate whether autoantibodies against BAFF (important B cell survival signal), APRIL (important plasma cell survival signal), or Interleukin-21 (important cytokine for immunoglobulin class switch) present an alternative mechanism for the development of the following primary antibody deficiencies (PADs): common variable immune deficiency (CVID) or selective IgA deficiency (sIgAD).Results: Two hundred thirty-two sera from patients with PADs were screened for autoantibodies against cytokines by ELISA. Statistical data analysis yielded a significant difference (p Conclusion: Whilst statistical analysis of ELISA results showed significant differences between patients and healthy controls, in our set of patients functional tests yielded no evidence for an involvement of autoantibodies against BAFF, APRIL, or IL-21 in the pathogenesis of CVID or sIgAD. |
| Databáze: | OpenAIRE |
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