Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012

Autor:	Meijer A, Jonges M, van Beek P, Cm, Swaan, Ad, Osterhaus, Rs, Daniels, Aeron Hurt, Mp, Koopmans
Předmět:	Travel Adolescent Molecular Sequence Data Neuraminidase Antiviral Agents Young Adult Influenza A Virus H1N1 Subtype Oseltamivir Treatment Outcome Spain Drug Resistance Viral Influenza Human Mutation Humans Sentinel Surveillance Netherlands
Zdroj:	Europe PubMed Central
Popis:	Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::105d01bb300cc2e69c91cc8b3fa35b08 http://europepmc.org/abstract/med/22971326 Zobrazit plný text záznamu