Influence of muramyl dipeptide on established experimental arthritis in rats
| Autor: | Jouzeau, J, Drelon, E, Gillet, G., Bannwarth, B, Fener, P., Charriere, G., Payan, E., Chauvelot-Moachon, L, Batt, A, Floquet, J. |
|---|---|
| Přispěvatelé: | Laboratoire de Physiopathologie et Pharmacologie Articulaire (CNRS URA 1288), Service de Rhumatologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Pharmacologie (URA CNRS 595 ), Centre du Médicament [Nancy], Université Henri Poincaré - Nancy 1 (UHP), Service d’Anatomie Pathologique [CHRU Nancy] |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Dose-Response Relationship
Drug [SDV]Life Sciences [q-bio] Rats Inbred WF Arthritis Experimental Rats Radiography body regions [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Immunoglobulin G parasitic diseases Animals Female Acetylmuramyl-Alanyl-Isoglutamine [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Glycoproteins |
| Zdroj: | Agents and actions. Supplements Agents and actions. Supplements, 1991, pp.191-5 |
| ISSN: | 0379-0363 |
| Popis: | International audience; The effects of MDP, a potent inducer of cytokines, were studied in four batches of Wistar Furth rats with established experimental arthritis. Arthritic rats were given a daily sc injection of 10, 100, 200 or 400 micrograms MDP respectively. Muramyl dipeptide increased the severity of clinical events in a dose-dependent manner, with the exception of the 10 micrograms dose which was ineffective. The levels of anti-collagen antibodies were not however significantly enhanced by MDP. Radiological lesions and histological changes were maximal at high dosage regimens. Paradoxically, the acute phase reactive alpha 1 glycoprotein was little affected by MDP treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|