Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure
| Autor: | Steffen, Hannah L. M., Anderson, Josephine L. C., Poot, Margot L., Lei, Yu, Connelly, Margery A., Bakker, Stephan J. L., Oorni, Katariina, Tietge, Uwe J. F. |
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| Přispěvatelé: | Molecular and Integrative Biosciences Research Programme, Biosciences, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
kidney transplantation
sPLA2-IIA group IIA phospholipase A2 QD415-436 Biochemistry LDL lipoprotein-proteoglycan binding susceptibility HUMAN AORTIC PROTEOGLYCANS cardiovascular mortality PARTICLES chronic graft failure AFFINITY COMPLICATIONS transplant vasculopathy eGFR estimated glomerular filtration rate cholesterol TV transplant vasculopathy AGGREGATION prospective HR hazard ratio LPBS lipoprotein-proteoglycan binding susceptibility RTR renal transplant recipient TC total cholesterol GF graft failure LOW-DENSITY LIPOPROTEINS MUSCLE-CELL PROTEOGLYCANS 1182 Biochemistry cell and molecular biology Kidney Failure Chronic lipids (amino acids peptides and proteins) proteoglycans atherosclerosis Research Article |
| Zdroj: | Journal of Lipid Research Journal of Lipid Research, Vol 62, Iss, Pp 100083-(2021) Journal of Lipid Research, 62:100083. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| ISSN: | 1539-7262 0022-2275 |
| Popis: | Lipoprotein-proteoglycan binding is an early key event in atherosclerotic lesion formation and thus conceivably could play a major role in vasculopathy-driven chronic graft failure and cardiovascular mortality in renal transplant recipients. The present study investigated whether lipoproteinproteoglycan binding susceptibility (LPBS) of apoBcontaining lipoproteins and levels of the classical atherosclerosis biomarker LDL-C were associated with cardiovascular mortality (n = 130) and graft failure (n = 73) in 589 renal transplant recipients who were followed up from at least 1 year after transplantation for 9.5 years. At baseline, LPBS was significantly higher in patients who subsequently developed graft failure than in those with a surviving graft (1.68 +/- 0.93 vs. 1.46 +/- 0.49 nmol/mmol, P = 0.001). Cox regression analysis showed an association between LPBS and chronic graft failure in an age-and sex-adjusted model (hazard ratio: 1.45; 95% CI, 1.14-1.85; P = 0.002), but no association was observed with cardiovascular mortality. LDL-C levels were not associated with graft failure or cardiovascular mortality. This study shows that measurement of cholesterol retention outperformed the traditionally used quantitative parameter of LDL-C levels in predicting graft failure, suggesting a higher relevance of proatherogenic function than the quantity of apoBcontaining lipoproteins in chronic kidney graft failure. |
| Databáze: | OpenAIRE |
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