Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice
| Autor: | Kazanis, I, Evans, KA, Andreopoulou, E, Dimitriou, C, Koutsakis, C, Karadottir, RT, Franklin, RJM |
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| Přispěvatelé: | Kazanis, Ilias [0000-0003-1035-0584], Karadottir, Thora [0000-0001-9675-2722], Franklin, Robin [0000-0001-6522-2104], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Neurogenesis
Mice Transgenic Article corpus callosum neural stem cell Mice Animals Stem Cell Niche lcsh:QH301-705.5 Myelin Sheath lcsh:R5-920 oligodendrocyte progenitor cell Age Factors subventricular zone myelination Brain oligodendroblast Cell Differentiation myelin Disease Models Animal Oligodendroglia remyelination lcsh:Biology (General) ageing subependymal zone demyelination lcsh:Medicine (General) OPC Biomarkers Demyelinating Diseases |
| Zdroj: | Stem Cell Reports Stem Cell Reports, Vol 8, Iss 3, Pp 685-700 (2017) |
| ISSN: | 2213-6711 |
| Popis: | Summary Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche. pOPCs are committed perinatally and retain their numbers through self-renewing divisions, while SEZ-derived cells are relatively “young,” being constantly born from neural stem cells. We compared the behavior of these populations, labeling SEZ-derived cells using hGFAP:CreErt2 mice, within the homeostatic and regenerating CC of the young-adult and aging brain. We found that SEZ-derived oligodendroglial progenitors have limited self-renewing potential and are therefore not bona fide OPCs but rather “oligodendroblasts” more similar to the neuroblasts of the neurogenic output of the SEZ. In the aged CC their mitotic activity is much reduced, although they still act as a “fast-response element” to focal demyelination. In contrast to pOPCs, they fail to generate mature myelinating oligodendrocytes at all ages studied. Graphical Abstract Highlights • SEZ-derived cells in the CC are oligodendroblasts and not OPCs • Oligodendroblasts have limited self-renewal capacity and do not make myelin • Oligodendroblasts respond rapidly after demyelination • Aging does not affect the oligodendroblast-pOPC balance Franklin, Kazanis, and colleagues compare the two oligodendrogenic pathways that co-exist in the corpus callosum. They demonstrate that, irrespective of age, adult neural stem cells generate oligodendroblasts; i.e., progenitors with limited self-renewal capacity that respond rapidly to focal demyelination but eventually fail to generate new myelin, which are different to parenchymal oligodendrocyte progenitor cells that drive remyelination. |
| Databáze: | OpenAIRE |
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