The innate immune response to products of phospholipid peroxidation☆

Autor: Weismann, David, Binder, Christoph J.
Jazyk: angličtina
Rok vydání: 2012
Předmět:
MFG-E8
Milk fat globule epidermal growth factor 8 (lactadherin)
CEP
carboxyethylpyrrole
OxCL
oxidized cardiolipin
OxLDL
oxidized LDL
C#
complement component #
Damage-associated molecular pattern
Apoptosis
Review
CHD
coronary heart disease
Biochemistry
PAMP(s)
pathogen-associated molecular pattern(s)
Epitopes
LDL
low-density lipoprotein
AMD
age-related macular degeneration
DAMP(s)
damage-associated molecular pattern(s)
POVPC
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphcholine
Phospholipids
ApoE
apolipoprotein E
CFHR
complement factor H related protein
CPS
capsular polysaccharide
CuOx-LDL
copper-oxidized LDL
Receptors
Pattern Recognition
CRP
C-reactive protein
MAA
malonacetaldehyde
NAb(s)
Natural antibodies
FAAB
2-formyl-3-(alkylamino)butanal
Oxidation-Reduction
OxPS
oxidized phosphatidylserine
Oxidized LDL
PUFA(s)
polyunsaturated fatty acid(s)
CL
cardiolipin
Lipid peroxidation
Biophysics
Pattern recognition receptor
IL-#
interleukin-#
CFH
complement factor H
PE
phosphatidylethanolamine
HBGM1
high-mobility group box 1
4-HNE
4-hydroxynonenal
Animals
Humans
PRR(s)
pattern recognition receptor(s)
TLR#
toll-like receptor
MDA
malondialdehyde
Cell Biology
HSP(s)
heat shock protein(s)
AGE(s)
advanced glycation end product(s)
Immunity
Innate
RAG
recombinase activating gene
OSE(s)
oxidation-specific epitope(s)
BSA
bovine serum albumin
Oxidation-specific epitope
MDHDC
4-methyl-1
4-dihydropyridine-3
5-dicarbaldehyde
PC
phosphocholine
Zdroj: Biochimica et Biophysica Acta
ISSN: 0006-3002
Popis: Lipid peroxidation occurs in the context of many physiological processes but is greatly increased in various pathological situations. A consequence of phospholipid peroxidation is the generation of oxidation-specific epitopes, such as phosphocholine of oxidized phospholipids and malondialdehyde, which form neo-self determinants on dying cells and oxidized low-density lipoproteins. In this review we discuss evidence demonstrating that pattern recognition receptors of the innate immune system recognize oxidation-specific epitopes as endogenous damage-associated molecular patterns, allowing the host to identify dangerous biological waste. Oxidation-specific epitopes are important targets of both cellular and soluble pattern recognition receptors, including toll-like and scavenger receptors, C-reactive protein, complement factor H, and innate natural IgM antibodies. This recognition allows the innate immune system to mediate important physiological house keeping functions, for example by promoting the removal of dying cells and oxidized molecules. Once this system is malfunctional or overwhelmed the development of diseases, such as atherosclerosis and age-related macular degeneration is favored. Understanding the molecular components and mechanisms involved in this process, will help the identification of individuals with increased risk of developing chronic inflammation, and indicate novel points for therapeutic intervention. This article is part of a Special Issue entitled: Oxidized phospholipids—their properties and interactions with proteins.
Highlights ► Phospholipid peroxidation results in the formation of oxidation-specific epitopes. ► Oxidation-specific epitopes are recognized by soluble and cellular pattern recognition receptors. ► Recognition by these receptors promotes the clearance of biological waste. ► This innate defense is challenged by increased oxidative stress, such as in chronic inflammation.
Databáze: OpenAIRE
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