Convulsant action of pentetrazol in rats with selective lesions of the hippocampal pyramidal cells with intracerebroventricular kainic acid

Autor:	Sj, Czuczwar, Turski L, Turski W, Kleinrok Z
Rok vydání:	1982
Předmět:	Male Kainic Acid Pyrrolidines Kindling Neurologic Pyramidal Tracts Animals Pentylenetetrazole Convulsants Rats Inbred Strains Hippocampus Injections Intraventricular Rats
Zdroj:	Scopus-Elsevier Europe PubMed Central
ISSN:	0379-0355
Popis:	Rats were injected uni- or bilaterally with intracerebroventricular kainic acid (0.1 micrograms per one ventricle in a volume of 5 microliters) and the animals were subsequently challenged with penetetrazol (PTZ) on the 21st day after the administration of the neurotoxin. PTZ was given either subcutaneously in a single dose of 70 mg/kg or intraperitoneally, one injection every 48 hours for a total of 15 trials, in doses of 20 mg/kg to induce kindled seizures. It was found that kainic acid-lesioned animals (especially those injected bilaterally) were more sensitive to the convulsant action of PTZ both in acute and kindled convulsions. The disruption of the hippocampal pyramidal projection to the septum may be responsible for these effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0be9f17ccb90507d56ead3a27321bfb9 https://pubmed.ncbi.nlm.nih.gov/7121135 Zobrazit plný text záznamu