Transcranial Electrical Stimulation generates electric fields in deep human brain structures

Autor: Louviot, Samuel, Tyvaert, Louise, Maillard, Louis, Colnat-Coulbois, Sophie, Dmochowski, Jacek, Koessler, Laurent
Přispěvatelé: Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Neurochirurgie [CHRU Nancy], Department of Biomedical Engineering [New York], City University of New York [New York] (CUNY), City College of New-York (USA) (DrEAM mobility grant), Rotary Club of Nancy (France), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Rok vydání: 2021
Předmět:
Zdroj: Brain Stimulation, Vol 15, Iss 1, Pp 1-12 (2022)
Brain Stimulation
Brain Stimulation, Elsevier, 2022, 15 (1), pp.1-12. ⟨10.1016/j.brs.2021.11.001⟩
ISSN: 1876-4754
1935-861X
DOI: 10.1016/j.brs.2021.11.001⟩
Popis: International audience; Background: Transcranial electrical stimulation (TES) efficiency is related to the electric field (EF) magnitude delivered on the target. Very few studies (n = 4) have estimated the in-vivo intracerebral electric fields in humans. They have relied mainly on electrocorticographic recordings, which require a craniotomy impacting EF distribution, and did not investigate deep brain structures. Objective: To measure the electric field in deep brain structures during TES in humans in-vivo. Additionally, to investigate the effects of TES frequencies, intensities, and montages on the intracerebral EF. Methods: Simultaneous bipolar transcranial alternating current stimulation and intracerebral recordings (SEEG) were performed in 8 drug-resistant epileptic patients. TES was applied using small high definition (HD) electrodes. Seven frequencies, two intensities and 15 montages were applied on one, six and one patients, respectively. Results: At 1 mA intensity, we found mean EF magnitudes of 0.21, 0.17 and 0.07 V/m in the amygdala, hippocampus, and cingulate gyrus, respectively. An average of 0.14 ± 0.07 V/m was measured in these deep brain structures. Mean EF magnitudes in these structures at 1Hz were 11% higher than at 300Hz (0.03 V/m). The EF was correlated with the TES intensities. The TES montages that yielded the maximum EF in the amygdalae were T7-T8 and in the cingulate gyri were C3-FT10 and T7-C4. Conclusion: TES at low intensities and with small HD electrodes can generate an EF in deep brain structures, irrespective of stimulation frequency. EF magnitude is correlated to the stimulation intensity and depends upon the stimulation montage.
Databáze: OpenAIRE
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