Frequency and clinical correlates of antiphospholipid antibodies arising in patients with SARS-CoV-2 infection: findings from a multicentre study on 122 cases

Autor:	MARIELE GATTO, Perricone, C., Tonello, M., Bistoni, O., Cattelan, A. M., Bursi, R., Cafaro, G., Robertis, E., Mencacci, A., Bozza, S., Vianello, A., Iaccarino, L., Gerli, R., Doria, A., Bartoloni, E.
Rok vydání:	2020
Předmět:	SARS-CoV-2 Pneumonia Viral COVID-19 Anticardiolipin Thrombosis Antiphospholipid Pneumonia Antiphospholipid Syndrome Antibodies Betacoronavirus Immunoglobulin M beta 2-Glycoprotein I Antibodies Anticardiolipin Immunoglobulin G Antibodies Antiphospholipid Humans Viral Coronavirus Infections Pandemics
Zdroj:	Università degli Studi di Padova-IRIS Scopus-Elsevier
ISSN:	0392-856X
Popis:	COVID-19 features include disseminated intravascular coagulation and thrombotic microangiopathy indicating a hypercoagulable state. We aimed to investigate antiphospholipid antibodies (aPL) prevalence and clinical relationships in a large cohort of COVID-19 patients.We analysed the prevalence and titres of serum aPL in 122 patients with COVID-19 and 157 with primary antiphospholipid syndrome (PAPS) and 91 with other autoimmune rheumatic diseases (oARD) for comparison. IgG/IgM anticardiolipin (aCL) and IgG/IgM anti-beta2glycoprotein I (β2GPI) were assayed using homemade ELISA, IgA aCL and anti-β2GPI by commercial ELISA kits and lupus anticoagulant (LAC) by multiple coagulation tests following updated international guidelines.Prevalence of IgG and IgM aCL and of IgG and IgM anti-β2GPI across COVID-19 patients were 13.4%, 2.7%, 6.3% and 7.1%, being significantly lower than in PAPS (p0.0001 for all). Frequency of IgG aCL and IgM anti-β2GPI was comparable to oARD (13.4% vs. 13.2% and 7.1% vs. 11%, respectively), while IgG anti-β2GPI and IgM aCL were lower (p0.01). IgA aCL and IgA anti-β2GPI were retrieved in 1.7% and 3.3% of COVID-19 patients, respectively. Positive LAC was observed in 22.2% COVID-19 vs. 54.1% of PAPS (p0.0001) and 14.6% of oARD (p=0.21). Venous or arterial thromboses occurred in 18/46 (39.1%) COVID-19 patients and were not associated with positive aPL (p=0.09).Thrombosis is a frequent manifestation during COVID-19 infection. However, prevalence and titres of aPL antibodies or LAC were neither consistently increased nor associated with thrombosis when measured at a single timepoint, therefore not representing a suitable screening tool in the acute stage of disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0ada04a69edd060a11e15e7e7e229b3b https://pubmed.ncbi.nlm.nih.gov/32723434 Zobrazit plný text záznamu