Elevated maternal plasma immunoreactive phospholipase A2 in human preterm and term labour

Autor: Ge, Rice, Shaun Brennecke, Kf, Scott, Gm, Smith, Ia, Rajkovic, Gj, Bishop
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Zdroj: Europe PubMed Central
Popis: Peripheral plasma concentrations of immunoreactive phospholipase A2 (irPLA2) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA2 did not significantly change during pregnancy (5.7 +/- 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA2 concentrations were significantly elevated in association with both preterm labour (13.3 +/- 2.4 ng/ml, n = 15, p less than 0.02) and labour at term (10.4 +/- 1.7, n = 23, p less than 0.02). These data suggest that maternal plasma irPLA2 may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.
Databáze: OpenAIRE