Effect of Helicobacter pylori eradication on extent of duodenal gastric metaplasia and grade of gastritis

Autor:	Joan Bago, Strinić D, Zb, Halle, Jandrić D, Tomić M, Bilić A, Bago P
Rok vydání:	2003
Předmět:	Male Metaplasia Helicobacter pylori Duodenum Gastric Mucosa Duodenal Ulcer Gastritis Humans Female macromolecular substances Middle Aged bacterial infections and mycoses Helicobacter Infections
Zdroj:	Europe PubMed Central Collegium antropologicum Volume 26 Issue 2
ISSN:	0350-6134 1848-9486
Popis:	The extent of the regression of duodenal gastric metaplasia (DGM) after the eradication of Helicobacter pylori infection is controversial. Therefore, we decided to assess the degree of DGM before, sex weeks and one year after H. pylori eradication. 105 consecutive Helicobacter pylori positive patients with endoscopically proven duodenal ulcer, with DGM and Helicobacter pylori infection were recruited for this study. The diagnosis of Helicobacter pylori infection was based on CLO-test and histology, and DGM was assessed on four bulb biopsies taken before, sex weeks and one year after Helicobacter pylori eradication. Histological assessment of Helicobacter pylori associated gastritis was performed according to the Sydney classification. Follow up study on 98 patients before, six weeks and one year after the eradication of Helicobacter pylori showed that the mean extent of DGM did not change significantly after eradication and did not differ when compared with 14 patients with persisting infection. Our results show that the inflammatory process related to Helicobacter pylori does not play the main role in the development of DGM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0a135e0314615c0aa355814f9e4461ea https://pubmed.ncbi.nlm.nih.gov/12528281 Zobrazit plný text záznamu