Chronic pain as expression of neural substrates. Issues from the neuronal dynamics and mutual relations
| Autor: | Brambilla, M., Manuguerra, M., Valente, M., Caramenti, G. C., Sotgiu, M. L., Gabriele Biella |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Neurons Ventral Thalamic Nuclei multielectrodes Action Potentials Peripheral Nervous System Diseases Somatosensory Cortex Cerebral cortex Sciatic Nerve Pain Intractable Rats Rats Sprague-Dawley Disease Models Animal Nonlinear Dynamics Thalamus connectivity Chronic Disease Neural Pathways Animals rat Nerve Net |
| Zdroj: | Archives Italiennes de Biologie 142 (2004): 275–283. info:cnr-pdr/source/autori:Brambilla M. 1, Manuguerra M. 1, Valente M. 1, Caramenti G.C. 2, Sotgiu M.L. 1, Biella G.E. 1/titolo:Chronic pain as expression of neural substrates. Issues from the neuronal dynamics and mutual relations/doi:/rivista:Archives Italiennes de Biologie/anno:2004/pagina_da:275/pagina_a:283/intervallo_pagine:275–283/volume:142 Europe PubMed Central Scopus-Elsevier |
| Popis: | The Thalamo-Cortical somatosensory loop shows important synaptic re-organization in cases of chronic pain. Animal models exhibit severe functional distortions, potentially related to the anatomic rearrangements. Connectivity and information theoretic measurement represent important tools to quantify the functional disarrays. We performed electrophysiological experiments with multisite, multielectrode simultaneous recordings in the Thalamus and in the Somatosensory Cortex. The recurrent anomalies in the analytic estimates induce to hypothesize a potential neurodynamical explanation of the sensory context. |
| Databáze: | OpenAIRE |
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