| Autor: |
Rc, Young, Mattis S, George Alexopoulos, Bs, Meyers, Rd, Shindledecker, Ak, Dhar |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0048-5764 |
| Popis: |
Performance on a verbal memory task and affective state were assessed in geriatric major depressives before and during 6 weeks of treatment with nortriptyline (NT) in a fixed-dose design study. Higher plasma NT concentration was associated with poorer free recall but better affective outcome. In contrast, higher plasma Z-10-hydroxynortriptyline (Z-10-OH-NT) concentration was associated with more efficient free recall. Concentration-effect relationships were noted in patients later classified as cognitively unimpaired using the Dementia Rating Scale after optimal treatment, rather than in those with residual cognitive impairment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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