Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection
| Autor: | Pizzorno, Andrés, Dubois, Julia, Machado, Daniela, Cartet, Gaëlle, Traversier, Aurelien, Julien, Thomas, Lina, Bruno, Bourdon, Jean-Christophe, Rosa-Calatrava, Manuel, Terrier, Olivier |
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| Přispěvatelé: | Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), University of Dundee, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gene Expression Regulation
Viral Protein Stability Ubiquitin-Protein Ligases lcsh:R lcsh:Medicine Gene Expression Proto-Oncogene Proteins c-mdm2 Viral Nonstructural Proteins [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Article Cell Line Protein Transport enzymes and coenzymes (carbohydrates) Influenza A virus Influenza Human [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Humans [SDV.IMM]Life Sciences [q-bio]/Immunology lcsh:Q Tumor Suppressor Protein p53 lcsh:Science neoplasms Signal Transduction |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.3746. ⟨10.1038/s41598-018-22139-6⟩ Scientific Reports, 2018, 8 (1), pp.3746. ⟨10.1038/s41598-018-22139-6⟩ Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-22139-6⟩ |
| Popis: | International audience; The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, notably via its non-structural protein (NS1), therefore altering Mdm2 stability, p53/Mdm2 interaction and regulatory loop during the time-course of infection. This study also highlights a new antiviral facet of Mdm2 possibly increasing the list of its many p53-independent functions. Altogether, our work contributes to better understand the mechanisms underlining the complex interactions between IAV and the p53 pathway, for which both NS1 and Mdm2 arise as key players. |
| Databáze: | OpenAIRE |
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