Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients

Autor:	Abu-Amero, Khaled K., Cabrera, Vicente M., Larruga, Jose M., Osman, Essam A., Gonzalez, Ana M., Saleh Al Obeidan
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Saudi Arabia Black People Glaucoma social sciences Exfoliation Syndrome DNA Mitochondrial humanities eye diseases Europe Haplotypes population characteristics Humans geographic locations Africa South of the Sahara Research Article
Zdroj:	Molecular Vision Web of Science
ISSN:	1090-0535
Popis:	Purpose To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population. Methods The mtDNA regulatory region and coding regions comprising mtDNA haplogroup diagnostic polymorphisms were sequenced in patients with PEG (n=94), healthy matched controls (free of PEG; n=112) and a healthy Saudi Arab population group (n=810). Results The Eurasian haplogroup T and the Sub-Saharan African Haplogroup L2 confer susceptibility to PEG, whereas the Eurasian haplogroup N1 was associated with reduced risk to develop PEG in the Saudi Arab population. Conclusions Mitochondrial haplogroups T and L2 may play a role in the development of PEG in the Saudi Arabian population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::056b8e61eb075e4786241cb28ce264cb http://europepmc.org/articles/PMC3044700 Zobrazit plný text záznamu