SEC31A-ALK Fusion Gene in Lung Adenocarcinoma

Autor:	Kim, Ryong Nam, Choi, Yoon-La, Lee, Mi-Sook, Lira, Maruja E, Mao, Mao, Mann, Derrick, Stahl, Joshua, Licon, Abel, Choi, So Jung, Van Vrancken, Michael, Han, Joungho, Wlodarska, Iwona, Kim, Jhingook
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Male Lung Neoplasms Genetic translocation Oncogene Proteins Fusion Vesicular Transport Proteins Receptor Protein-Tyrosine Kinases Case Report Exons Adenocarcinoma Middle Aged Anaplastic lymphoma kinase hemic and lymphatic diseases Humans Oncogene Fusion SEC31A In Situ Hybridization Fluorescence
Zdroj:	Cancer Research and Treatment : Official Journal of Korean Cancer Association
ISSN:	2005-9256 1598-2998
Popis:	Anaplastic lymphoma kinase (ALK) fusion is a common mechanism underlying pathogenesis of non-small cell lung carcinoma (NSCLC) where these rearrangements represent important diagnostic and therapeutic targets. In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. The conjoined region in the fusion transcript was generated by the fusion of SEC31A exon 21 and ALK exon 20 by genomic rearrangement, which contributed to generation of an intact, in-frame open reading frame. SEC31A-ALK encodes a predicted fusion protein of 1438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus. FISH studies suggested that SEC31A-ALK was generated by an unbalanced genomic rearrangement associated with loss of the 3'end of SEC31A. This is the first report of SEC31A-ALK fusion transcript in clinical NSCLC, which could be a novel diagnostic and therapeutic target for patients with NSCLC. ispartof: Cancer Research and Treatment vol:48 issue:1 pages:398-402 ispartof: location:Korea (South) status: published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05150f812457db59bde3026882bc81ec http://europepmc.org/articles/PMC4720077 Zobrazit plný text záznamu