| Autor: |
Frankl, J, Piaggi, P, Foley, Je, Krakoff, J, Votruba, Sb |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Obesity (Silver Spring, Md.). 25(1) |
| ISSN: |
1930-739X |
| Popis: |
To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain.Subjects had assessment of percent body fat (%fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8.2 ± 5.5 years).In vitro lipolysis (r = 0.47, P0.0001) and adipocyte size (r = 0.49, P0.0001) were strongly associated with %fat. In vitro lipolysis (P = 0.04) but not adipocyte size (P = 0.44) was associated with whole-body fat oxidation. Adipocyte size was not associated with rate of percent weight gain (P = 0.20) but was negatively associated with rate of percent fat mass gain (P = 0.01). In vitro lipolysis was negatively associated with rate of percent weight gain (P = 0.02) and had a marginal negative association with rate of percent fat mass gain (P = 0.08).These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole-body lipid oxidation and subsequent weight gain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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