Analysis of reciprocal translocations by chromosome painting: applications and limitations of the technique

Autor:	carla rosenberg, Blakemore, K. J., Kearns, W. G., Giraldez, R. A., Escallon, C. S., Pearson, P. L., Stetten, G.
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	Adult Chromosomes Human Pair 14 Chromosomes Human Pair 15 Chromosomes Human Pair 13 Nucleic Acid Hybridization humanities Translocation Genetic Fetus Pregnancy Humans Female Chromosomes Human Pair 3 Chromosome Deletion Research Article Gene Library
Zdroj:	ResearcherID Scopus-Elsevier
Popis:	Fluorescent in situ hybridization with chromosome-specific DNA libraries (chromosome painting) is an important new method for assessing chromosome rearrangements. In the research presented in this paper, two familial reciprocal translocations have been studied in the balanced and unbalanced forms, using both traditional G-banding techniques and chromosome painting. Although for each case two chromosomes were involved in the rearrangement, we found that only one chromosome library was suitable for detecting the translocation. These findings illustrate both the potential and the limitations of chromosome painting as a diagnostic tool in cytogenetics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0452d41af0b3749c9707afd911d56bff https://europepmc.org/articles/PMC1682652/ Zobrazit plný text záznamu