The relationship between Obsessive-Compulsive symptoms and PARKIN genotype: The CORE-PD study
| Autor: | Sharp, Madeleine E, Caccappolo, Elise, Mejia-Santana, Helen, Tang, Ming-X, Rosado, Llency, Orbe Reilly, Martha, Ruiz, Diana, Louis, Elan D, Comella, Cynthia, Nance, Martha, Bressman, Susan, Scott, William K, Tanner, Caroline, Waters, Cheryl, Fahn, Stanley, Cote, Lucien, Ford, Blair, Rezak, Michael, Novak, Kevin, Friedman, Joseph H, Pfeiffer, Ronald, Payami, Haydeh, Molho, Eric, Factor, Stuart A, Nutt, John, Serrano, Carmen, Arroyo, Maritza, Pauciulo, Michael W, Nichols, William C, Clark, Lorraine N, Alcalay, Roy N, Marder, Karen S |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Heterozygote Obsessive-Compulsive Disorder Parkinson's Genotype Ubiquitin-Protein Ligases obsessive-compulsive Clinical Sciences Neurodegenerative Article Genetics 2.1 Biological and endogenous factors Humans Genetic Predisposition to Disease parkin Genetic Testing Aetiology Age of Onset Aged Parkinson's Disease Neurology & Neurosurgery Neurosciences Parkinson Disease Human Movement and Sports Sciences Middle Aged neuropsychological Brain Disorders Neurological Mutation Female |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society, vol 30, iss 2 |
| Popis: | BackgroundFew studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).MethodsThe Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.ResultsAmong patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13).ConclusionsFirst, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society. |
| Databáze: | OpenAIRE |
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