A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
| Autor: | Harm HogenEsch, Gijbels, M. J. J., Offerman, E., Hooft, J., Bekkum, D. W., Zurcher, C. |
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| Přispěvatelé: | Other departments, Instituut voor verouderings- en vaatziekten onderzoek TNO |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Dermatitis
triamcinolone broxuridine hematopoietic cell Rodent Diseases squamous epithelium Mice remission Adrenal Cortex Hormones Animals gene mutation Mast Cells macrophage function Biology Skin Animal neutrophil epidermis hyperplasia Immunohistochemistry intercellular adhesion molecule 1 Mice Inbred C57BL Disease Models Animal Chronic Disease Mutation histopathology Cyclosporine Research Article |
| Zdroj: | American Journal of Pathology, 3, 143, 972-982 American journal of pathology, 143(3), 972-982. Elsevier Inc. Scopus-Elsevier |
| ISSN: | 0002-9440 |
| Popis: | Chronic proliferative dermatitis is a new spontaneous mutation in C57BL/Ka mice. Breeding results suggest an autosomal recessive mode of inheritance. Mutant mice develop skin lesions at the age of 5 to 6 weeks. The lesions occur in the ventral and dorsal skin of the body, whereas ears, footpads, and tail are not involved. The lesions are characterized by epidermal hyperplasia, hyper- and parakeratosis, and single cell necrosis of keratinocytes. The dermis and epidermis are infiltrated by granulocytes and macrophages, and occasionally subcorneal and intracorneal microabscesses are formed. The number of mast cells in the dermis progressively increases with age. There is dilatation and proliferation of dermal capillaries. Similar lesions develop in the mouth, esophagus, and forestomach, which, in the mouse, are all lined by orthokeratinizing stratified squamous cell epithelium. Studies with bromodeoxyuridine confirm the increased rate of epithelial cell proliferation. Most inflammatory cells in the affected skin express Mac-1, and few express the T lymphocyte marker CD3. There is increased expression of intercellular adhesion molecule-1 on keratinocytes and endothelial cells. Infiltration of neutrophils and macrophages are also seen in the liver, lung, and several joints. The disease could not be transferred by bone marrow or spleen transplants into irradiated normal syngeneic hosts. Treatment of the mice with triamcinolone, a long-acting corticosteroid, resulted in nearly complete regression of the lesions over a period of 4 weeks, whereas systemic cyclosporin A treatment was ineffective. Chemicals/CAS: broxuridine, 59-14-3; cyclosporin A, 59865-13-3, 63798-73-2; intercellular adhesion molecule 1, 126547-89-5; triamcinolone, 124-94-7; Adrenal Cortex Hormones; Cyclosporine, 59865-13-3 |
| Databáze: | OpenAIRE |
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