Correction for Alexander-Bloch et al., Imaging local genetic influences on cortical folding
| Jazyk: | angličtina |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Proc Natl Acad Sci U S A Proceedings of the National Academy of Sciences of the United States of America |
| Popis: | Significance Major gaps remain in our understanding of mechanisms that underlie the folding of the human cerebral cortex. Stereotyped folding in specific cortical locations could be explained by a corresponding anatomical pattern of genetic influences on cortical development, but no direct evidence supports this explanation. Here, we use high-resolution brain MRI to show the existence of the predicted pattern of genetic influences on the thickness of the cerebral cortex, leveraging the prediction that shared genetic influences during development create covariability of cortical thickness in adult neuroanatomy. Anatomically local covariability in cortical thickness has a genetic basis, is symmetric between cortical hemispheres, shows consistency across independent datasets, and may influence patterns of surface folding on the human brain. Recent progress in deciphering mechanisms of human brain cortical folding leave unexplained whether spatially patterned genetic influences contribute to this folding. High-resolution in vivo brain MRI can be used to estimate genetic correlations (covariability due to shared genetic factors) in interregional cortical thickness, and biomechanical studies predict an influence of cortical thickness on folding patterns. However, progress has been hampered because shared genetic influences related to folding patterns likely operate at a scale that is much more local ( |
| Databáze: | OpenAIRE |
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