New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation After Canine Gastrointestinal Simulated Digestion
| Autor: | Theysgeur, Sandy, Cudennec, Benoit, Deracinois, Barbara, Perrin, Claire, Guiller, Isabelle, Lepoudère, Anne, Flahaut, Christophe, Ravallec, Rozenn |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
in vitro gastrointestinal digestion
Protein Hydrolysates Swine Dipeptidyl Peptidase 4 In Vitro Techniques Cat Diseases Article Mass Spectrometry Gastrointestinal Hormones lcsh:QD241-441 Dogs lcsh:Organic chemistry Fish Products Animals Humans Dog Diseases Hydrolysis digestive oral and skin physiology DPP-IV inhibitory peptides Biological Transport Overweight Animal Feed glucagon-like peptide 1 cholecystokinin Gastrointestinal Tract Glucose Cats Caco-2 Cells Peptides bioactive peptides fish byproduct hydrolysate Tilapia |
| Zdroj: | Molecules, Vol 26, Iss 136, p 136 (2021) Molecules Volume 26 Issue 1 |
| ISSN: | 1420-3049 |
| Popis: | Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer. |
| Databáze: | OpenAIRE |
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