| Autor: |
J E, Horowitz, J A, Kosmicki, A, Damask, D, Sharma, G H L, Roberts, A E, Justice, N, Banerjee, M V, Coignet, A, Yadav, J B, Leader, A, Marcketta, D S, Park, R, Lanche, E, Maxwell, S C, Knight, X, Bai, H, Guturu, D, Sun, A, Baltzell, F S P, Kury, J D, Backman, A R, Girshick, C, O'Dushlaine, S R, McCurdy, R, Partha, A J, Mansfield, D A, Turissini, A H, Li, M, Zhang, J, Mbatchou, K, Watanabe, L, Gurski, S E, McCarthy, H M, Kang, L, Dobbyn, E, Stahl, A, Verma, G, Sirugo, M D, Ritchie, M, Jones, S, Balasubramanian, K, Siminovitch, W J, Salerno, A R, Shuldiner, D J, Rader, T, Mirshahi, A E, Locke, J, Marchini, J D, Overton, D J, Carey, L, Habegger, M N, Cantor, K A, Rand, E L, Hong, J G, Reid, C A, Ball, A, Baras, G R, Abecasis, M A, Ferreira |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
medRxiv |
| Popis: |
The need to identify and effectively treat COVID-19 cases at highest risk for severe disease remains critical. We identified five common genetic loci (two novel) that modulate both COVID-19 susceptibility and severity, implicating TMPRSS2, IFNAR2, CCHCR1, TCF19 and SLC6A20 as potential targets. A high genetic burden was strongly associated with increased risk of hospitalization and severe disease among COVID-19 cases, especially among individuals with few known clinical risk factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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