Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center
| Autor: | Silvio Mihaljević, Aleksandar Kibel, Mario Štefanić, Ljubica Glavaš-Obrovac, Boris Takač, Željko Krznarić, Marina Samardžija, Ljerka Pinotić, Josip Milas, Ivan Segec |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Base Sequence Croatia Crohn’s disease ulcerative colitis Inflammatory bowel disease interleukin-23 receptor single nucleotide polymorphism genotype population inflammation cytokine autoimmune Receptors Interleukin Inflammatory Bowel Diseases Interleukin-23 Polymerase Chain Reaction Polymorphism Single Nucleotide digestive system diseases Tertiary Care Centers Young Adult Case-Control Studies association studies inflammatory bowel disease genetic polymorphism single nucleotide Humans Female DNA Primers |
| Zdroj: | Collegium antropologicum Volume 37 Issue 4 |
| ISSN: | 0350-6134 1848-9486 |
| Popis: | The Interleukin-23 signalling pathway is important for the differentiation of TH17 lymphocytes and is involved in the pathogenesis of Inflammatory bowel disease. Polymorphisms in the IL-23 receptor gene were previously found to be associated with Inflammatory bowel disease in various populations. The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn’s disease and ulcerative colitis in a Croatian patient population. A total of 50 patients with Crohn’s disease and 93 patients with ulcerative colitis, as well as 99 healthy control subjects were included in the study. The results deter- mined a significantly higher occurrence of rs11209026 in control group compared to patients with inflammatory bowel disease, suggesting a protective effect of this polymorphism. The rs11209026 variant was strongly associated with Crohn’s disease, but it was absent in ulcerative colitis. However, there was no significant association between the rs7530511 poly- morphism with either ulcerative colitis or Crohn’s disease. Associations presented in this study give potentially impor- tant insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn’s disease pathogenesis in the Cro- atian population. |
| Databáze: | OpenAIRE |
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